Triglyceride (neutral fat) levels

• The normal value for triglycerides (neutral fats) is less than 150 mg/dLAnd high levels increase the risk of arteriosclerosis and cardiovascular disease.
• T-type mutation in DNA region rs1260326Research shows that people with
• appropriateMeal management/aerobic exercise/weight controlIt is possible to improve neutral fat levels by

Overview Triglycerides (neutral fats) have the role of storing energy ingested from meals in the body, but excessive amounts can have negative effects on the body. The normal value for triglycerides is 150 mg/dL or less, but if it exceeds this, you may be diagnosed with hypertriglyceridemia. High triglyceride levels increase the risk of cardiovascular diseases such as angina pectoris, myocardial infarction, valvular heart disease, and arrhythmia, as well as arteriosclerosis and diabetes. Causes of high triglyceride levels include excessive calorie intake, diets high in sugar and fat, excessive alcohol intake, lack of exercise, and genetic factors. Therefore, in order to keep triglycerides within the normal range, it is important to eat a healthy diet, exercise regularly, control your weight, and consume appropriate amounts of alcohol. A study by Zhou et al. from Huazhong University of Science and Technology revealed that high levels of triglycerides (neutral fats) are associated with a DNA region called rs1260326. There are three genotypes in this DNA region: TT, TC, and CC, and it was found that people with the T genotype tend to have high triglycerides.

Triglycerides (neutral fats) are lipids that have the role of storing energy in the body from meals.The normal value is 150 mg/dL or less, and if it exceeds this, hypertriglyceridemia is diagnosed (1).

What is the cause of high neutral fat?

The causes of triglyceride exceeding the standard value are classified into the following five categories.

• Excessive calorie intake:Amount of food that exceeds the daily calorie consumption
• Meals high in sugar and fat:Regular consumption of sweets, fried foods, and soft drinks
• Excessive intake of alcohol:Promotes neutral fat synthesis in the liver
• Lack of exercise:Decrease in fat burning opportunities
• Genetic factors:T-type mutation in DNA region rs1260326

What happens if you have high neutral fat?

If neutral fat remains above 150 mg/dL, the risk of the following diseases increases.

• cardiovascular disease(angina pectoris, myocardial infarction, valvular heart disease, arrhythmia)
• arteriosclerosis(Plaque accumulation on blood vessel walls)
• diabetes(increased insulin resistance)
• acute pancreatitis(Risk of onset increases when 500mg/dL or higher)

Standard values and classification of neutral fats

How to lower neutral fat

The following four things are important to keep neutral fat within the normal range.

• Meal management:Limit carbohydrates and fats and actively consume blue fish (EPA and DHA)
• Aerobic exercise:150 minutes or more of walking/jogging/swimming per week
• Weight management:Aim to maintain BMI below 25
• Alcohol restrictions:1 cup of sake (20g of pure alcohol) or less per day

Relationship between DNA region rs1260326 and triglyceride level

A study by Zhou et al. (1) from Huazhong University of Science and Technology found that the DNA region rs1260326 was associated with triglyceride (neutral fat) levels.

• There are three genotypes of rs1260326: TT, TC, and CC.
• Genotype with T-type mutation(TT/TC) people tend to have high triglycerides

Genotype distribution in Japanese (rs1260326)

The proportion of Japanese people with TT type is approximately twice the world average (16.7%) (33.8%), and there is a genetic tendency to have high triglyceride levels.

Q1. What is triglyceride (neutral fat)?

Triglycerides (neutral fats) are lipids that help the body store energy from food.The normal value is 150 mg/dL or less, and if it exceeds this, hypertriglyceridemia is diagnosed. Excessive accumulation increases the risk of arteriosclerosis and cardiovascular disease (1).

Q2. What is the cause of high neutral fat?

The main cause isExcessive calorie intake, sugary/fatty foods, excessive alcohol intake, lack of exercise, genetic factorsThere are five. Carriers of the T mutation in the DNA region rs1260326 have a genetic tendency to have high levels of triglycerides (1).

Q3. How to lower neutral fat?

Dietary management (restricting carbohydrates and fats, intake of blue fish), aerobic exercise for at least 150 minutes per week, maintaining a proper weight, limiting alcohol intakeis effective.

Q4. Can the risk of developing triglycerides be determined through genetic testing?

By examining the genotype of the DNA region rs1260326,Genetic predisposition to high neutral fat levelsYou can figure out whether Studies have shown that people with the T genotype tend to have higher levels of triglycerides (1).