life satisfaction
- Life satisfaction is an indicator of how happy you feel with your life.and is closely related to the DNA region rs8089474 near the gene RAB27B.
- AG type/AA type gene typehave a high ability to transmit information about happiness through the hippocampal CA3 neural circuit, and tend to have high life satisfaction.
- The prevalence of type AA in Japanese people is39.6%This is a low percentage compared to the global average of 61.4%.
Overview Are you happy now? Everyone wants to be happy. Happiness is expressed by "life satisfaction". Recent research has shown that genetic factors also influence life satisfaction. Research led by major organizations such as the United Nations and national governments has revealed that in addition to age, annual income, and health status, specific genes are related to feelings of happiness. According to recent research, it has been reported that a certain region near the gene "RAB27B" is likely to affect life satisfaction. Life satisfaction is an indicator related to the richness of life. You may be able to enrich your life by finding out your genetic type related to your life satisfaction through genetic testing and acting on the results. 2. Rationale A study conducted in Amsterdam, the Netherlands, showed that a specific type of gene near the gene "RAB27B" influences life satisfaction. The DNA region "rs8089474" has three genotypes: "GG type," "GA type," and "AA type." It has been reported that ``AG types'' and ``AA types'' tend to have a high level of life satisfaction because they have a high ability to convey information related to happiness. The genetic types of Japanese people are ``GG type'' at 15.1% (least common), ``AG type'' at 47.5% (most common), and ``AA type'' at 37.4%. On the other hand, worldwide, the genetic types are 4.7% (the least common), 33.9% are the AG type, and 61.4% are the AA type (the most common). Globally, 61.4% of people with type AA feel happy, while in Japan it is 37.4%. Since life satisfaction is influenced by multiple factors, it cannot be determined by genetic type alone, but looking at the genetic type of Japanese people, we found that life satisfaction tends to be slightly higher. 3. Mechanism of action The gene ``RAB27B'' associated with ``life satisfaction'' is located on chromosome 18 of the 24 human chromosomes. The ``RAB27B'' gene is abundantly present in the ``hippocampus'', an organ of the brain, and plays a role in regulating the information transmission function of ``CA3'', a neural circuit within the hippocampus. "CA3" transmits information related to "happiness" such as a sense of happiness and satisfaction, and influences how much information related to "happiness" we receive in our daily lives. Based on this, it is thought that the gene "RAB27B" and "life satisfaction" are very closely related. The DNA region "rs8089474" is one of the single nucleotide polymorphisms (SNVs) that is attracting attention as it is related to "life satisfaction."
What is life satisfaction?
Life satisfaction is an indicator of how satisfied and happy you are with your life.It is an important measure used in the United Nations' World Happiness Report and surveys by national governments, and the latest research has revealed that in addition to environmental factors such as age, annual income, and health status, genetic factors also influence life satisfaction.
Is life satisfaction related to genes?
Research by Baselmans et al., Vrije Universiteit Amsterdam (2019, Nature (Published in Genetics) revealed that the DNA region rs8089474 near the gene RAB27B is associated with life satisfaction.
- rs8089474 hasGG type, GA type, AA typeThere are three genotypes of
- AG type/AA typehave a high ability to convey information related to happiness and tend to have high life satisfaction.
- A 2016 study by Okbay et al. (Nat Genet) also confirmed the association between genes and subjective well-being.
What is the genetic mechanism related to life satisfaction?
The gene RAB27B is located on chromosome 18 and is abundant in the hippocampus, an organ of the brain.It plays a role in regulating the information transmission function of the CA3 neural circuit within the hippocampus.
- CA3 neural circuit:Conveys information about feelings of happiness and satisfaction and influences sensitivity to "happiness" in daily life
- RAB27B gene:Regulates the information transmission function of CA3 and influences the amount of signals of happiness
- rs8089474：A single nucleotide polymorphism (SNV) located near the RAB27B gene, which is attracting attention due to its association with life satisfaction.
Relationship between genetic type and life satisfaction
| Genotype | Information transmission ability | Trends in life satisfaction |
|---|---|---|
| GG type | standard | reference level |
| GA type | somewhat expensive | slightly higher tendency |
| AA type | expensive | high tendency |
Data related to genes and life satisfaction
Comparison of genotype distribution in Japanese and the world (rs8089474)
| Genotype | Percentage of Japanese people | percentage of the world |
|---|---|---|
| GG type | 13.7% | 4.6% |
| GA type | 46.6% | 33.9% |
| AA type | 39.6% | 61.4% |
Globally, the percentage of people with type AA who are easy to feel happy is61.4%In contrast, in Japanese39.6%This is a low percentage. On the other hand, the Japanese GG type13.7%This is approximately three times the world average of 4.6%, reflecting the genetic characteristics of the Japanese population.
Comparison of genotype distribution in Japanese and the world (rs4799464)
| Genotype | Percentage of Japanese people | percentage of the world |
|---|---|---|
| CC type | 8.8% | 14.7% |
| CT type | 41.8% | 47.3% |
| TT type | 49.2% | 37.9% |
Comparison of genotype distribution in Japanese and the world (rs2834018)
| Genotype | Percentage of Japanese people | percentage of the world |
|---|---|---|
| GG type | 55.5% | 62.7% |
| GA type | 37.9% | 32.8% |
| AA type | 6.4% | 4.3% |
Rationale for testing
External DNA domain: Life satisfaction
The gene region that most strongly influences life satisfaction is rs8089474. The distribution of isomorphic genotypes in Japan is as follows.
- GG 13.7 %
- GA 46.6 %
- AA 39.6 %
Another gene region related to life satisfaction is rs4799464. The distribution of isomorphic genotypes in Japan is as follows
- CC 8.8 %
- CT 41.8 %
- TT 49.2 %
Another gene region related to life satisfaction is rs2834018. The distribution of isomorphic genotypes in Japan is as follows
- GG 55.5 %
- GA 37.9 %
- AA 6.4 %
Basis for inspection
A study by Baselmans et al. at Vrije Universiteit Amsterdam revealed that life satisfaction is linked to genes. There is a region called rs8089474 in the human genome, and there are two types of mutations, G and A, in the gene in this region. It was found that people with the G type mutation tend to have higher life satisfaction.
The DNA region investigated this time
Schematic diagram of DNA map present in cells
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Related genes
| Related genes | RAB27B |
|---|---|
| Related genes | RPL12P40 |
| Related genes | C21orf62-AS1 |
Frequently asked questions (FAQ)
Q1. What is life satisfaction?
Life satisfaction is an indicator of how satisfied and happy you are with your life.This is a scale used in the United Nations' World Happiness Report, and research has shown that it is influenced by genetic factors as well as environmental factors such as age, annual income, and health status.
Q2. Is life satisfaction related to genes?
Yes.Research by Baselmans et al., Vrije Universiteit Amsterdam (2019, Nature Genetics) found that the DNA region rs8089474 is associated with life satisfaction.There are three genotypes of rs8089474: GG, GA, and AA, and people with the AG type and AA type have a high ability to convey information related to happiness and tend to have a high level of life satisfaction.
Q3. What is the distribution of the genotype (rs8089474) related to life satisfaction in Japanese people?
The genotype distribution of rs8089474 in Japanese people isGG type 13.7%, GA type 46.6%, AA type 39.6%It is. Worldwide, 4.6% are GG type, 33.9% are GA type, and 61.4% are AA type, and Japanese people are characterized by a lower proportion of AA type than the world average.
Q4. What is the genetic mechanism related to life satisfaction?
geneRAB27B is located on chromosome 18It is abundantly present in the hippocampus of the brain. It plays a role in regulating the information transmission function of neural circuit CA3 in the hippocampus, and influences the transmission of information related to feelings of happiness and satisfaction. CA3 transmits information about ``happiness'' and is involved in how happy we feel in our daily lives.
Q5. What can we do to increase life satisfaction?
Genetic type alone does not determine life satisfaction.Moderate exercise, quality sleep, maintaining social connections, and practicing mindfulnessIt is possible to improve life satisfaction by improving environmental factors such as: It is important to know your type through genetic testing and take action based on the results.
References
- Reference link 1: 2019 Jan., Bart M. L. Baselmans, Nature Genetics.
- Reference link 2: DNA Information on region “rs8089474” NIH
- Reference link 3: 2020 May., Arias‐Hervert, Erwin R.,Physiological Reports.
- Reference link 4: 2018 Jan., Takuya Sasaki, Nature Neuroscience.
- Reference link 5: 2016 Jun., Aysu Okbay, Nat Genet