interest in drinking
- Interest in drinking is associated with the gene ADH1B (DNA region rs1229984)However, those with type C mutation tend to have a higher desire to drink alcohol.
- The genotype distribution of Japanese people isTT type 53.4%, TC type 39.3%, CC type 7.2%, which is significantly different from the world average.
- excessive drinkingLiver disease, cardiovascular disease, alcoholismAdequate dosage is important as it increases the risk of
Overview Drinking interest refers to the interest or desire to drink alcoholic beverages. People are interested in drinking for a variety of reasons, including social factors, personal experiences, and cultural backgrounds. Drinking is part of social life in many cultures. For example, at gatherings with friends and family, celebrations, and special occasions, alcohol is used to liven up the atmosphere. Alcohol is also said to have a relaxing effect and a mood-enhancing effect, and drinking can provide temporary relief for people looking to relieve stress or change their mood. People who have a habit of drinking especially after work or on weekends choose alcohol as a means of relaxation. On the other hand, too much interest in drinking can have negative effects on your health. Excessive drinking is known to increase the risk of liver disease, cardiovascular disease, and alcohol dependence. Therefore, it is not necessarily a bad thing to be interested in drinking alcohol, but it is important to keep it in moderation. A study by Matoba and colleagues at the RIKEN Center for Integrative Medical Science revealed that an interest in drinking is associated with a DNA region called rs1229984. There are three genotypes in this DNA region: TT, TC, and CC, and it was found that people with the C type mutation tend to be more interested in drinking alcohol.
What is your interest in drinking?
Drinking interest is the interest or desire to consume alcoholic beverages.A study by Matoba et al. (2020, Nat Hum Behav) from the RIKEN Center for Integrative Medical Sciences revealed that this interest is associated with the DNA region rs1229984 of the gene ADH1B.
Reasons for interest in drinking
Interest in drinking is formed through the combined effects of the following three factors:
- Social factors:Alcohol is used to liven up the atmosphere at gatherings with friends and family, celebrations, and special events.
- Psychological factors:Alcohol's relaxing and mood-elevating effects make it a popular choice as a means to relieve stress and change your mood.
- Genetic factors:Type C mutation in the DNA region rs1229984 of the ADH1B gene affects drinking desire
Relationship between interest in drinking and health risks
Excessive interest in drinking increases the following health risks:
| Risk classification | Specific diseases/symptoms | influence |
|---|---|---|
| liver disease | Fatty liver, alcoholic hepatitis, cirrhosis | Decreased liver function/hepatic failure |
| cardiovascular disease | Hypertension, arrhythmia, cardiomyopathy | Heart and blood vessel damage |
| addiction | Alcoholism/tolerance formation | Withdrawal symptoms/interference with social life |
| Others | Increased cancer risk/mental illness | Negative effects on the whole body |
According to the guidelines of the Ministry of Health, Labor and Welfare,Approximately 20g of pure alcohol per day (equivalent to one medium bottle of beer)is considered a guideline for a moderate amount of alcohol.
Guidelines for moderate alcohol consumption
- Beer:1 medium bottle (500ml)
- Sake:1 cup (180ml)
- Wine:2 glasses (about 200ml)
- Whiskey:1 double (approx. 60ml)
The link between genes and interest in drinking
Relationship between DNA region rs1229984 and desire to drink alcohol
A study by Matoba et al. (2020, Nat Hum Behav) from the RIKEN Center for Integrative Medical Science found that the DNA region rs1229984 is strongly associated with an interest in drinking.
- There are three genotypes of rs1229984: TT, TC, and CC.
- Genotype with type C mutationpeople tend to be more interested in drinking alcohol
- Related genesADH1Bencodes alcohol dehydrogenase and is directly involved in alcohol metabolism
Comparison of genotype distribution in Japanese and the world (rs1229984)
| Genotype | Percentage of Japanese people | percentage of the world |
|---|---|---|
| TT type | 53.4％ | 0.2％ |
| TC type | 39.3％ | 9.2％ |
| CC type | 7.2％ | 90.4％ |
Japanese people have a T mutation prevalence rate of 92.7% (TT+TC), which is much higher than the world average of 9.4%, and their genetic characteristics regarding alcohol metabolism are different from those in the world.
Rationale for testing
External DNA region: Interest in drinking
The gene region that most strongly influences interest in drinking is rs1229984. The distribution of isomorphic genotypes in Japan is as follows.
- TT 53.4 %
- TC 39.3 %
- CC 7.2 %
Basis for inspection
A study by Matoba and colleagues at the RIKEN Center for Integrative Medical Science revealed that interest in drinking is linked to genes. There is a region called rs1229984 in the human genome, and there are two types of mutations, T and C, in the gene in this region. It was found that people with the T-type mutation tend to be more interested in drinking alcohol.
The DNA region investigated this time
Schematic diagram of DNA map present in cells
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Related genes
| Related genes | ADH1B |
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Frequently asked questions (FAQ)
Q1. What is your interest in drinking?
Drinking interest is the interest or desire to consume alcoholic beverages.Social factors, psychological factors, and genetic factors have a complex effect. Studies have shown that people with the C variant of the gene ADH1B (DNA region rs1229984) tend to be more interested in drinking alcohol.
Q2. What genes are associated with interest in drinking?
Most strongly associated with interest in drinkingADH1B gene (alcohol dehydrogenase 1B)It is. There are three genotypes in the DNA region rs1229984: TT, TC, and CC, and those with the C mutation tend to be more interested in drinking alcohol. In Japanese, the distribution is 53.4% for TT type, 39.3% for TC type, and 7.2% for CC type.
Q3. Are there any health risks if I have a strong interest in drinking?
Excessive drinking increases the risk of liver disease, cardiovascular disease, and alcohol dependence.According to the Ministry of Health, Labor and Welfare's guidelines, a moderate amount of alcohol to drink per day is approximately 20g of pure alcohol (equivalent to one medium bottle of beer).
Q4. What is the difference between the genotype distribution in Japan and the rest of the world?
In Japanese, 53.4% have TT type and 39.3% have TC type.T-type mutation prevalence rate is 92.7%In contrast, the CC type accounts for 90.4% worldwide. Japanese people have genetic characteristics related to alcohol metabolism that are significantly different from the world average.
References
- Reference link 1: 2020 Mar., Nana Matoba, Nat Hum Behav