DNA鑑定|一生の悩みを2日で解決|国内自社ラボDNA鑑定

childhood obesity

Image of childhood obesity
  • Childhood obesity (childhood obesity) is a condition in which the BMI falls within the 95th percentile for people of the same age and gender.and are at risk for diabetes, high blood pressure, and cardiovascular disease.
  • C-type mutation in DNA region rs476828A Cambridge University study finds that people with
  • appropriateImproving diet, increasing exercise, and changing behaviorIt is possible to reduce and prevent the risk of developing the disease.

Overview Childhood obesity is a condition in which excess fat accumulates in a child's body, negatively impacting their health and well-being. Obesity in children is assessed using standard growth charts by comparing weight and height, and children are usually considered obese if their BMI is at or above the 95th percentile of their peers of the same age and gender. Obese children have a rounder body shape and store more fat, especially in the abdomen and hips, than their healthy-weight peers. This excess fat can lead to health problems such as diabetes, high blood pressure, and high cholesterol, which is a risk factor for cardiovascular disease. It also increases your risk of breathing difficulties, sleep apnea, and joint problems. Obesity has not only physical but also significant psychological effects, lowering self-esteem and increasing the risk of bullying. Additionally, getting tired easily during exercise can also become a problem, creating a vicious cycle. The causes of obesity are genetic, behavioral, and environmental, and are related to diet, lack of exercise, genetic factors, and socio-economic background. Care and prevention require a comprehensive approach, including improved diet, increased physical activity, behavioral changes, and medical care as needed. A study by Wheeler et al. at the University of Cambridge revealed that the risk of childhood obesity is associated with a DNA region called rs476828. There are three genotypes in this DNA region: TT, TC, and CC, and it was found that people with the C genotype tend to have a higher risk of childhood obesity.

What is childhood obesity?

Childhood obesity (childhood obesity) is a condition in which excess fat accumulates in a child's body, and is diagnosed if the BMI falls within the 95th percentile or higher for a child of the same age and gender.It has a negative impact on health and well-being and is a risk factor for conditions such as diabetes, high blood pressure, and cardiovascular disease.

Causes and risk factors of childhood obesity

Childhood obesity is caused by a complex of genetic, behavioral, and environmental factors. The main risk factors are:

  • Genetic factors:People with type C mutation in DNA region rs476828 tend to be at higher risk
  • Improper eating habits:Excessive intake of high-calorie, high-fat foods
  • Lack of exercise:Decrease in physical activity and increase in screen time
  • Socioeconomic background:Restricted access to healthy foods

Main symptoms and health risks of childhood obesity

Obese children compared to their healthy weight peersFat accumulates in the abdomen and hipswill be done. It can cause the following health problems:

  • Metabolic abnormalities:diabetes, high blood pressure, high cholesterol
  • Respiratory system:Dyspnea, sleep apnea syndrome
  • Locomotor system:Joint problems, fatigue during exercise
  • Psychological impact:Lower self-esteem, increased risk of bullying

Difference between childhood obesity and adult obesity

Comparison items childhood obesity adult obesity
Diagnostic criteria BMI 95th percentile or higher BMI 30 or more
Main cause Genetics + diet + lack of exercise Lifestyle + Aging + Genetics
psychological impact Significant bullying and low self-esteem Focus on social prejudice and depression
complications Effects on growth/early metabolic abnormalities Cardiovascular disease/diabetes
treatment approach Family unit behavioral change Personal lifestyle improvement

Prevention and countermeasures for childhood obesity

Care and prevention require a comprehensive approach.

  • Meal improvement:A balanced diet consisting mainly of vegetables and fruits
  • Increased exercise:60 minutes or more of moderate to vigorous physical activity per day
  • Behavioral change:Screen time limit (within 2 hours per day)
  • Medical intervention:Expert support when needed

The link between genes and childhood obesity

Relationship between DNA region rs476828 and onset risk

A study by Wheeler et al. from the University of Cambridge found that the DNA region rs476828 is associated with the risk of childhood obesity.

  • There are three genotypes of rs476828: TT, TC, and CC.
  • Genotype with type C mutationpeople tend to be at higher risk of childhood obesity

Genotype distribution in Japanese (rs476828)

Genotype Percentage of Japanese people percentage of the world
TT type 47.9% 57.0%
TC type 42.6% 36.9%
CC type 9.4% 5.9%

Proportion of people with each genetic type in Japan in genetic region rs476828

  • TT
    47.9%
  • TC
    42.6%
  • CC
    9.4%

Percentage of people in the world with each genetic type in the rs476828 gene region

  • TT
    57.0%
  • TC
    36.9%
  • CC
    5.9%

Percentage of people with each genetic type in Japan in genetic region rs17782313

  • TT
    54.1%
  • TC
    38.9%
  • CC
    6.9%

Percentage of people in the world with each genetic type in the rs17782313 gene region

  • TT
    59.2%
  • TC
    35.4%
  • CC
    5.3%

Rationale for testing

Superficial DNA region: childhood obesity

The gene region that most strongly influences childhood obesity is rs476828. The distribution of isomorphic genotypes in Japan is as follows.

  • TT
    47.9 %
  • TC
    42.6 %
  • CC
    9.4 %

Another gene region associated with childhood obesity is rs17782313. The distribution of isomorphic genotypes in Japan is as follows

  • TT
    54.1 %
  • TC
    38.9 %
  • CC
    6.9 %

Basis for inspection

A study by Wheeler et al. at the University of Cambridge revealed that the risk of childhood obesity is linked to genes. There is a region called rs476828 in the human genome, and there are two types of mutations, T and C, in the gene in this region. It was found that people with type C mutation tend to have a higher risk of childhood obesity.

The DNA region investigated this time

Schematic diagram of DNA map present in cells

Image

Related genes

Related genes RNU4-17P
Related genes RNU4-17P

Frequently asked questions (FAQ)

Q1. What is childhood obesity?

Childhood obesity (childhood obesity) is a condition in which excess fat accumulates in a child's body.The diagnosis is made when the BMI falls within the 95th percentile or higher for people of the same age and gender. It carries a risk of diabetes, high blood pressure, and cardiovascular disease.

Q2. What is the cause of childhood obesity?

The main cause isGenetic factors, inappropriate diet, lack of exercise, socio-economic backgroundThere are four. People with type C mutation in the DNA region rs476828 tend to be at higher risk.

Q3. How can childhood obesity be prevented?

Improved diet (balanced diet), increased exercise (more than 60 minutes of physical activity per day), behavioral changes (limited screen time), medical intervention is effective if necessary.

Q4. Can genetic testing determine the risk of childhood obesity?

By examining the genotype of DNA regions rs476828 and rs17782313,Understand the risk trends of childhood obesityYou can. Research from the University of Cambridge has found that people with the genotype C tend to be at higher risk.

References